![]() Indeed, the spinal demyelinating disorders that have been reported in those patients who have suffered from COVID-19 rather than on the people already living with diagnosed or undiagnosed primary demyelinating disorders. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo SARS-CoV-2 mediated spinal cord demyelinating diseases. On the other hand, patients with known primary demyelinating disorders may experience an exacerbation of pre-existing neurological features ( Roy et al., 2021). On the one hand, SARS-CoV-2 infection may lead to brain and spinal cord demyelination. The inter-relationship between demyelinating disorders and COVID-19 has two dimensions. Further, spinal cord complications associated with COVID-19 are being widely reported ( Sánchez-Raya and Sampol, 2020). COVID-19 related peripheral nervous system (PNS) involvement has mostly been seen in the form of Guillain-Barré syndrome (GBS) and myositis ( Roy et al., 2021, Yavarpour-Bali and Ghasemi-Kasman, 2020, Lahiri and Ardila, 2020, Asadi-Pooya, 2020, Nepal et al., 2020). Among the severe central nervous system (CNS) manifestations, stroke is one of the most frequently reported ( Roy et al., 2021, Yavarpour-Bali and Ghasemi-Kasman, 2020, Lahiri and Ardila, 2020, Asadi-Pooya, 2020), meanwhile demyelinating disorders and seizures are now being increasingly documented as well ( Roy et al., 2021, Yavarpour-Bali and Ghasemi-Kasman, 2020, Lahiri and Ardila, 2020, Asadi-Pooya, 2020, Ellul et al., 2020, Nepal et al., 2020). Neurological features may occasionally precede the typical constitutional or respiratory symptoms of the coronavirus infectious disease of 2019 (COVID-19) ( Lahiri and Ardila, 2020). It is currently known that several central and peripheral nervous system disorders may appear following SARS-CoV-2 infection ( Roy et al., 2021, Yavarpour-Bali and Ghasemi-Kasman, 2020). Apart from pulmonary, renal, gastrointestinal, and hematological complications, neurological manifestations have also been reported frequently ( Roy et al., 2021). However, with time it has behaved as a virus with the potential to cause multi-system involvement. Initially, SARS-CoV-2 was primarily considered as a respiratory pathogen. The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has now prevailed across the world since WHO declared it as a pandemic on March 11, 2020.
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